The Planets Gustav Holsts Suite Essay Example For Students

The Planets Gustav Holsts Suite Essay Upon deciding what piece of music to write about it was very difficult to decide, since before taking this class the only classical musician I knew was Beethoven. However, I came across the planets. So I decided to give I try. It just took a play button, which transported me into a world of mystery. As the symphony started with mars I felt as though I was going in a space ship of those that came on the star wars saga. It as the song progressed it felt as though there was a battle in space. Listing to this while in the dark made it easier for me to see what was really happening. We will write a custom essay on The Planets Gustav Holsts Suite specifically for you for only $16.38 $13.9/page Order now I can see bullets fly by me closer and closer, until this bullet hit me and the ship pieces disperse into space as the song did too. There is a moment of silence when am awaken in to the world of lord of the rings. I see my self at the elves garden standing in the castles balcony looking at the roses. As the piece keeps going I see my black clouds covering the horizon, with darkness and mystery upon. For some reason there is a sense of peace even though at some parts it feels as thought there is a war about to start. This made me feel like this was countering, like they say after the storm the sun will come out. Next was mercury a dangerous. t first it felt as thought I was running away from someone or something. But it doesn’t feel like I’m running away from something dangerous. As the piece kept going I started to see why I was running, I was running like Bambi in the Disney movie. I can see birds and butterflies, flying on top of my head in circles. I started to run with the birds faster and faster making my war across a big green field. I don’t know why this image comes to my heard but as keep listening a can see a lot of animals running too. They are jumping across the green field. Jupiter starts and with it I start to remember my grandma back home. I can see her coming in from a long trip. I can see her coming closer to me bringing nothing but a smile to my face. As viola and baritones appear, I can imagine our reunite. This piece only brings image of happy ending, like those of Disney movies. I can see people throwing confetti to the sky, celebrating and parting. All this happiness is suddenly, wiped away, because with the start of Saturn. I hear something approaching me slowly and slowly. It is not a scary thing coming but it is a sense of realization. I see that the person coming is me but as an old man. I look frail and fragile. I see my self-walking slowly and for each step I take my steps become slower and slower. As the piece progresses, I start to hear bells. This piece just bring sadness into my head all I can think now is that for every day that passes by I am near the end. But the end of what? I don’t understand. As Saturn comes to the end I see the old me just standing there without moving. It seems as thought the end has come, like the suffering and everything happening in life has finally stop. Uranus stars and I can imagine a giant man walking along a giant sidewalk. In the sidewalk I can see a lot of soldiers marching. There is a feeling of mystery with the piccolo and clarinets. Neptune was the last piece. This was my favorite one because it had something that the rest of the other planets did not and that is a women chorus. This gives a feeling of going into heaven a reaching the divine one. .uf1f0d1fb3fa8082f741b6f8ca03afda7 , .uf1f0d1fb3fa8082f741b6f8ca03afda7 .postImageUrl , .uf1f0d1fb3fa8082f741b6f8ca03afda7 .centered-text-area { min-height: 80px; position: relative; } .uf1f0d1fb3fa8082f741b6f8ca03afda7 , .uf1f0d1fb3fa8082f741b6f8ca03afda7:hover , .uf1f0d1fb3fa8082f741b6f8ca03afda7:visited , .uf1f0d1fb3fa8082f741b6f8ca03afda7:active { border:0!important; } .uf1f0d1fb3fa8082f741b6f8ca03afda7 .clearfix:after { content: ""; display: table; clear: both; } .uf1f0d1fb3fa8082f741b6f8ca03afda7 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .uf1f0d1fb3fa8082f741b6f8ca03afda7:active , .uf1f0d1fb3fa8082f741b6f8ca03afda7:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .uf1f0d1fb3fa8082f741b6f8ca03afda7 .centered-text-area { width: 100%; position: relative ; } .uf1f0d1fb3fa8082f741b6f8ca03afda7 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .uf1f0d1fb3fa8082f741b6f8ca03afda7 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .uf1f0d1fb3fa8082f741b6f8ca03afda7 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .uf1f0d1fb3fa8082f741b6f8ca03afda7:hover .ctaButton { background-color: #34495E!important; } .uf1f0d1fb3fa8082f741b6f8ca03afda7 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .uf1f0d1fb3fa8082f741b6f8ca03afda7 .uf1f0d1fb3fa8082f741b6f8ca03afda7-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .uf1f0d1fb3fa8082f741b6f8ca03afda7:after { content: ""; display: block; clear: both; } READ: Music downloading, illegal or not ? EssayI can see other people reaching to the heavens as well as the women chorus joins with the bells. The feeling of reaching the end of the symphony, is unforgettable the women chorus starts to become fade out slowly becoming fainter until there is a slight difference between silence and sound. I was left trilled after listening to this symphony. I never felt this way it was an amazing experience feeling as thought I was flying through the cosmos of the universe. However I wonder if there is Pluto. And if there is I’m guessing it would probably give images of unknown and mystery.

10 Facts for an Anxiety Disorder Case Study to Strike the Audience

10 Facts for an Anxiety Disorder Case Study to Strike the Audience If students must investigate the anxiety disorder case study, they should present the facts and evidence. Otherwise, the paper will lack research and can be banned because of unreliable and not real information. That’s why students should do a thorough research, analyze data, and then present it in the paper. 10 Facts about Anxiety Disorder Case Study Look at the following facts to see what you should look for. According to research data, women are more vulnerable to stress factors and more frequently suffer from anxiety disorders. The Epidemiological Catchment Area has found out that 9.7% of females from the five chosen states of America had all anxiety disorders compared to 4.7% of men. 11.7% of women aged from 25 to 44 suffer from anxiety disorders when only 4.7% of men of the same age turn to their health advisers with the same mental problem. 2.8% of American adult population (18-54 years old) realizes that they have generalized anxiety disorder after clinical testing yearly. As a rule, kids and teenagers acquire such a health complication, but today the number of ill adults grows daily. People who are diagnosed with an anxiety disorder have more chances to get injuries, cardiovascular problems like too low or too high blood pressure and heart diseases, and be hospitalized than those who have no problems with the nervous system. The scientific survey shows that the most typical anxiety disorder is a specific phobia. Almost 12% of the world population has a specific phobia or even phobias. Patients have a rapid heartbeat, shortness of breath, and shiver. For instance, there was a 9-year-old boy who was afraid of buttons. Agoraphobia is an example of possible anxiety disorders. Patients who have to deal with it feel uncomfortable and even experience panic attacks when they cannot find the way out of the situation or an exit door. When they feel extreme pressure, they try to escape the situation. For example, a 30-year old woman experienced her first panic attack when she was surrounded by football fans at a football game. She had hardly found an ambo to get to the ambulance. One of the most dangerous and common disorders is a generalized anxiety disorder. It lasts long (6 months and more) and can be provoked by any stress factor. What’s more a patient feels bad all the time and the health state is getting more and more complicated daily. A patient experiences constant fatigue, cannot concentrate on something, is unable to rest, is very nervous, and has muscle stiffness and insomnia. A person can also complain of headaches, abdominal pain, fast heart beating, and restlessness. For instance, a 28-year-old Caucasian woman turned to her physician because she felt pain in her joints and back. In addition, she couldn’t fall asleep and worried about each detail of her life. Her doctor diagnosed GAD that was the result of depression, alcohol addiction, hypertension, and daily stresses. People who cannot stand being among people or hold a speech in front of the audience suffer from social phobia. They try to avoid public places and often blush, sweat, and cannot speak distinctly in case they experience phobia attack. For example, a 30-year old Jim was afraid to communicate with people he didn’t know, and his wife had to solve all social issues. When his boss sold the business, the man had to deal with new people and responsibilities. Consequently, those worries brought him to a hospital. Many people experience post-traumatic stress disorder. It’s the result of traumas which a person get at some car crash, natural disasters, assault, child abuse, hostage cases, and serious accidents (at war, job, or military service). A person is afraid to live that situation again and starts avoiding vehicles, dark places, etc. For example, a disabled veteran had PTSD and he couldn’t live normally because he was always afraid of enemies and possible shots. He didn’t trust his family and friends and thought that the danger was everywhere. His physician prescribed a number of pills to let him fall asleep, feel less worried, and get rid of muscle spasms. Approximately 1% of people around the world have selective mutism. It’s inability to speak in some situation or at the presence of some people. People don’t speak even if they can be punished. A 4-year-old Greek girl refused to speak and used only gestures in conversation after she had been bitten by a dog. It turned out that she took offense at her mother because her mother hadn’t protected her from the dog (the girl played unsupervised outside). People have separation anxiety disorder when they feel anxiety being away from some people (friends, relatives, etc.) or their apartments. A 13-year-old boy couldn’t attend school and stay at his friend’s home because of SAD. So, you can see that a good paper requires reliable and trustworthy facts. Don’t be lazy and get striking and good information to support your research paper. References: Sue. A case study about panic and agoraphobia in an ex-serving member of the Australian Defence Force. https://at-ease.dva.gov.au/veterans/resource-library/case-studies/case-study-panic-and-agoraphobia Wikipedia. Anxiety disorder. https://en.wikipedia.org/wiki/Anxiety_disorder#Causes K. Silverman. Case Study: Disgust and a Specific Phobia of Buttons. https://jaacap.org/article/S0890-8567(09)60644-4/fulltext Dana Moorer, SPT Kaelin Hocker, SPT. Generalized Anxiety Disorder Case Study 2017. https://www.physio-pedia.com/Generalized_Anxiety_Disorder_Case_Study_2017 Thomas A. Richards. Social Phobia/Anxiety Case Study: Jim. http://anxietynetwork.com/content/social-anxiety-case-study FQ Facts. Case Study 2. fqfacts.com/case-studies/case-studies-anxiety-disorders/ Journal of Medical Case Reports (2009). Selective Mutism due to a Dog Bite Trauma in a 4-year-old Girl: a Case Report. https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-3-100

Business environment Essay Example | Topics and Well Written Essays - 1000 words

Business environment - Essay Example 2009, p. 98). UK house prices have shown strong growth within nominal as well as real terms from since 1998, particularly when contrasted with earlier house price phases. An important justification for this appreciation lays in the development of basic demand issues, most significantly the increase in standard household incomes and the drop in standard mortgage interest rates. This increased both the ability to finance housing and households' capacity to service a bigger mortgage for set earnings. Lessening of mortgage lending limitations as well as a liking prejudice towards home ownership as well appear seem to have supported house price demand, however increasing demand for owner occupied housing further seems to incorporate a major â€Å"quasi speculative† (Andrews?2009, p. 103) component, motivates by beliefs of earlier capital benefits carrying on in the upcoming times. Answer 2: In equilibrium, the rate of renting a home should be equal to the price of owning it and hen ce to the actual client cost of accommodation, this technique represented an asset-pricing approach. Interest rates not just control the debt service price of funding a house acquisition, they as well modify the discount factor for evaluating the return on capital, and hence this should be negatively correlated with house costs. Within the UK effectual mortgage rates drifted downwards considerably during the 1998 and 2007, the phase where house costs goes up on their fastest. The similar downhill drift is marked for estimated mortgage charges, which relate to fresh borrowers. Because of comparatively steady inflation rates all over this phase the paths of nominal as well as actual interest rates â€Å"moved in lockstep† (Andrews?2009, p. 187), so that both the nominal and real weight of mortgage borrowing â€Å"fell in parallel†, decreasing the cost of debt sponsored home ownership for a set levels of earnings as well as house prices. Demand altering aspects, for insta nce, population or income development should be shown in increasing rental fees and house costs if rental fees precisely reveal the accurate expenditure for space, in which case surplus demand for housing facilities need not considerably have an effect on the price-to-rent ratio. Demand alterations linked with income and population growth had formed majority of the upward shift. Answer 3: On its most fundamental level, study of the course of UK house prices should start with a difference amid housing demand and supply, as well as issues deciding alterations in demand and supply. One of the conservative hypothetical structures for modeling house prices is an ‘inverted demand function approach’, whereby house prices are described as a function of the â€Å"physical housing stock, real income and other demand shifters† (Smith & Searle, 2010, p. 166). Changing factors incorporate population increase in addition to other demographic alterations, the ease of use of cre dit, interest rates, as well as likely or delayed appreciation; housing supply is normally â€Å"assumed fixed in the short term† (Smith & Searle, 2010, p. 98), which requires that demand alterations settle on house prices as an interim measure. The key basis of increased quantity demand for housing, that is, the need for further housing units, is alters within the total amount of households, and this will under plausible suppositions is likely to bid up house prices. Expansion in the quantity of households either can be because

DYADIC RELATIONSHIPS and (B) CHARISMATIC AND TRANSFORMATION LEADERSHIP Case Study - 1

DYADIC RELATIONSHIPS and (B) CHARISMATIC AND TRANSFORMATION LEADERSHIP - Case Study Example e to share their part of version over a particular issue; this gives subordinates confidence and sense of ownership that they are a valuable part of the organisation. And, at the same time, this brings total and practical rather than superficial participation in decision making, besides, this exchange relationship motivates them to avail more subordinate autonomy. In these times, many would not disagree that organisations succeed when they allow their organisational leadership to extend autonomy and ensure the concept of decentralisation aggregately. 2. Comment on â€Å"Dyadic relationships typically progress through a series of ups and downs with shifts in attitudes as the two parties attempt to reconcile their desire for autonomy with their desire for closer involvement† The LMX theory is under-developed. It has yet to fully define the all areas and way exchange relationships evolve over time (Yukl, 2010, p.239). This theory suggests that exchange relationships construct and evolve in a very smooth but continuous fashion, taking their base from the initial impressions. However, some longitudinal studies contend that the LMX relationships develop faster and remain stable. But, other researches do not agree with this claim, they contend that dyadic relationships undergo a series of ups and downs, where roles of behaviours cannot be undermined. The closer elaboration surfaces some facts. Without any doubt, perceptions play a vital role in developing or dissolving any exchange relationships. Many further studies within this area would greatly be helpful in analysing and understanding the each party’s perceptions of the relationships. Charismatic leaders are by nature transformational (Lussier, 2010, p.349). However, not all transformational leaders become successful in achieving their transforming results via the charismatic of their personalities. Charismatic leaders prefer to promote their personal image and identification in contrast to transformational

Arguments upon the American dream Essay Example | Topics and Well Written Essays - 1000 words

Arguments upon the American dream - Essay Example As stated by renowned American author, F. Scott Fitzgerald, in the novel ‘The Great Gatsby’, the American dream is the pursuit of happiness. Every American man has been trying his best in order to do better and earn more by getting a better job. In the novel, the protagonists, or the members of the family try their best to achieve as many possessions as they can as well as acquire wealth and make something of themselves. They each have a dream of their own and try their level best to achieve the status of a rich person. In the modern day and age as well, most Americans share the same dream and have tried their best to climb up on the wealth ladder in order to be able to have a higher purchasing power so that they can earn a higher status for themselves in society and be able to demand for more products. (The American Dream - F. Scott Fitzgerald) However, this very dream has been denounced according to the American people, commonly known as the Whites, because of the influx of a large population that has been setting and establishing itself within America, for a very long time. The Whites feel prejudice within their hearts against immigrants for the sole reason that they feel that the other people have been taking their jobs away and have thus, in the process, taken away their ‘American dream’. Because of this, the Whites are not being able to fulfil their desires due to the shortage of jobs and employment opportunities as well as seats in educational institutions, schools and colleges. The White race within the confines of the United States has also been shifting over the years because of migrations by people from different countries, belonging to different races. According to a number of reports, over the years, the shift has been so much that half of America consists of the Whites now and the rest of it consis ts of people belonging to other races, mostly the Blacks and the Browns. (Government Census) A race is a line of people measured on the basis of their skin colour; there are a number of people that are ‘racists’ or those that discriminate on the basis of a person’s skin colour and do not offer him jobs or educational opportunities because of the same reason. For a long time, White people have been known to be racists because there has been a history of them discriminating against people belonging to other races. Today in America people belonging to other races have been facing this problem very harshly and are finding it difficult to survive there. The Whites simply mention that they are forced to take these steps in order for them to be able to retain their jobs and other opportunities and not have everything being given away to other people. Being racist is a bad thing because discrimination on any ground is not a civil action to carry out. However, for the mos t part, there is a certain amount that the country might lose out on by losing a White majority because a vast amount of industrialization has been brought about by the Whites. They have been able to contribute a great amount to the world of modern information and technology with the help of the advent of the internet as well as other global communication facilities. They have set the bar for the

Vitamin D Impact on the Liver and Kidney

Vitamin D Impact on the Liver and Kidney Revised vitamin D copy Sources and forms of vitamin D Vitamin D, also termed calciferol, is a fat-soluble secosteroid compound that is an essential regulatory factor for calcium and phosphate metabolism in humans and animals. Its biological functions involve a physiological action in bone formation and mineralization, muscle contraction, nerve signal modulation and transmission as well as many cellular metabolic effects in various organs. There are two forms of vitamin D that are metabolically important; vitamin D2 or ergocalciferol and vitamin D3 or cholecalciferol. The nutritional sources of both forms are limited to certain types of foods that naturally contain vitamin D and therefore it is added to some foods as a supplement. 1.1.1- Exogenous (Diet) Both forms of vitamin D (D2 and D3) are exogenously obtained in low quantities from some types of food in the diet. Vitamin D2 is rare as it is produced from fungal and plant sources such as mushrooms and cereals, as a result of irradiation, by ultraviolet photons, of the plant sterol ergosterol. When these foods are ingested, ergocalciferol is absorbed into the blood. Vitamin D3 , on the other hand, is available in very low amounts from animal sources including oily fish such as salmon and mackerel; other sources include meat, liver, cheese, cod liver oil, eggs and fortified foods such as margarine and milk (Holick, 2006; Engelsen et al., 2005; Nowson et al., 2004). Farmed salmon, for example, contains only 25% of the vitamin D levels present in wild salmon, however, the amount of vitamin D in canned food may affected by modern processing methods (Chen et al., 2007). 1.1.2- Endogenous In humans the principal precursor of vitamin D3 is cholesterol which is obtained from the diet. Cholesterol is initially converted to 7-dehydrocholesterol, provitamin D3, through the action of enzymes termed the mucosal dehydrogenase complex, present in the small intestine. Provitamin D3, is then incorporated within chylomicrons and transported to the skin where temperature dependent photoisomerisation processing of 7-dehydrocholesterol takes place in epidermal cells resulting in the production of D3. Within the epidermal cells, vitamin D3 undergoes photocoversion to its isomers 5,6-transvitamin D3 and suprasterol, a process which relies on the amount of ultraviolet radiation absorbed; inadequate sunlight exposure compromises this process (Holick, 2003; Iqbal, 1994). Sunlight exposure is therefore a crucial element in the regulation and enhancement of endogenous cholecalciferol production (Dusso, et al., 2005; Iqbal, 1994; Reichel, et al., 1989; Smith, 1988). Once photoconversion is completed, cholecalciferol binds to Vitamin D Binding Protein (VDBP) and transported to the liver for further metabolic processing. Vitamin D metabolism Both forms of vitamin D (D2 and D3) undergo similar metabolic activation in the liver and kidney respectively to produce the physiologically active form 1,25-dihydroxyvitamin D3. 1.2.1- Skin The skin is characterized by two layers, the outer epidermal region, consisting of several strata, and the inner dermal layer. Skin exposure to UVB rays in sunlight, characterized by a wavelength of 290 nm to 315 nm, allows the initial steps of vitamin D synthesis to occur using the substrate 7-dehydrocholesterol (7-DHC) as illustrated in step 1 of Figure 1. UVB absorption by 7-DHC is thought to occur actively in the stratum basale and stratum spinosum regions of the epidermal layer. The substrate 7-DHC is an important intermediate of cholesteryl ester biosynthesis from squalene. During the reaction, 7-DHC forms procholecalciferol through B ring opening of the steroid structure. This transition state is relatively unstable and can further undergo photocatalyzed reactions to form lumisterol and tachysterol (Wolpowitz and Gilchrest, 2006). Lumisterol and tachysterol have been shown to prevent vitamin D reaching intoxicating levels and do not have any direct vitamin D effects (Bouillon et al., 1998). In addition to this protective mechanism, previtamin D poisoning is also prevented because this is an equilibrium reaction that allows cholecalciferol to revert back to 7-DHC (Webb, 2006). Cholecalciferol (previtamin D3) is produced upon double bond rearrangement of procholecalciferol and remains in the extracellular space where it becomes bound to the ubiquitous VDBP (Holick, 2005). Figure1. Sources and steps of vitamin D synthesis in the three major sites: skin, liver and kidney (Figure obtained from Wolpowitz and Gilchrest, 2006). 1.2.2- Liver Cholecalciferol that has been transported to the liver undergoes the first step of its bioactivation, the hydroxylation of carbon 25 (Dusso, et al., 2005) by two hepatic enzymes; the microsomal and mitochomdrial 25-hydroxylases (Deluca et al., 1990). In hepatic cellular microsomes and mitochondria, vitamin D3 is hydroxylated at carbon 25 and transformed to 25-hydroxyvitamin D3 by both 25-hydroxylase enzymes. This enzyme complex requires the presence of essential catalytic cofactors including nicotinamide adenine dinucleotide phosphate (NAPDH), flavin adenine dinucleotide (FAD), ferredoxin and molecular oxygen for this reaction to proceed (Sahota and Hosking, 1999; Ohyama et al., 1997; Kumar, 1990). Recently, large numbers of hepatic cytochrome P-450 enzymes exhibiting 25-hydroxylase action have been identified in vitamin D activation pathways; these enzymes include CYP27A1, CYP3A4, CYP2D25 and CYP2R1 (Dusso, et al., 2005; Cheng et al., 2003; Sawada et al., 2000). However, CYP2R1 is b elieved to be the principal enzyme in the hepatic pathway and the presence of a genetic mutation in its gene may compromise the outcome of this process; both CYP27A1 and CYP2D25 demonstrate high capacity and low affinity features, therefore, their activity is considered insignificant in this pathway (Dusso, et al., 2005; Cheng et al., 2003; Sawada et al., 2000). This metabolic step is inefficiently regulated, i.e. the levels of 25-hydroxy vitamin D are elevated as dietary intake of vitamin D increases. Consequently, over 95% of 25-hydroxyvitamin D in serum circulates as 25-hydroxyvitamin D3 which has a half-life of approximately three weeks, and is therefore used in the assessment of vitamin D status (Dusso, et al., 2005; Reichel et al., 1989). The metabolically inert 25-hydroxyvitamin D3 is then transported to the kidney for the second step of its bioactivation. 1.2.3- Kidney The second step of vitamin D3 bioactivation takes place at the proximal convoluted tubule of the kidney. Hydroxylation occurs at C-1 of 25-hydroxyvitamin D3 whereby the highly active 25-hydroxyvitamin D3 1-ÃŽ ±-hydroxylase (CYP27B1) incorporates a hydroxyl group to Carbon-1 of the first ring to form the biologically active metabolite 1,25-dihydroxyvitamin D3 (Holick,2006; Dusso, et al., 2005; Deluca et al, 1990; Reichel, et al., 1989). The high activity of 1-ÃŽ ±-hydroxylase (CYP27B1) present in kidney is not unique to this organ and can also be found in some other organs (Bouillon, 1998). The renal hydroxylation of 25-hydroxyvitamin D3 is the rate-limiting step in the production of 1,25-dihydroxyvitamin D3 and is well regulated. An alternative pathway of hydroxylation of 25-hydroxyvitamin D3 within renal mitochondria takes place at Carbon-24 to form 24,25-dihydroxyvitamin D3 which is metabolically inert. This process is catalyzed by renal 24-ÃŽ ±-hydroxylase in response to 1-ÃŽ ±-hy droxylase suppression. However, 24-ÃŽ ±-hydroxylase not only initiates the attachment of the hydroxyl group at Carbon-24 but also enhances the dehydrogenation of 24,25-dihydroxyvitamin D3 and hydroxylation at Carbon 23 and 26 (Sahota and Hosking, 1999; Bouillon, 1998; Reichel, et al., 1989). Renal hydroxylases require the presence of catalytic cofactors that enhance their synthetic activities during this process. Figure 2 shows the details of vitamin synthesis including the enzymes and cofactors required for each step. Figure2. Enzymes, cofactor and intermediates compounds of vitamin D metabolism (Bouillon et al. 1998) 1.2.4- Regulation of vitamin D metabolism Numbers of factors have been demonstrated to be important in the regulation of vitamin D metabolism; particularly significant its regulation through renal production. The factors involved in this regulation comprise parathyroid hormone (PTH), calcitonin, dietary calcium and phosphate, insulin and insulin-like growth factor and 1,25-dihydroxyvitamin D3 itself (Holick,2006; Deluca, 2004; Sahota and Hosking, 1999). Key interactions of vitamin D with its receptor are known to initiate gene regulation. These mechanisms have been studied using vitamin D analogues which have revealed the mechanism of assembly of transcriptions factors and promotion of gene regulation by this molecule (Cheng et al., 2004; Wu et al., 2002). Figure 3 shows the effect of various regulators on vitamin D metabolism. Figure 3: Alternate pathway for vitamin D3 under different metabolic conditions of low mineral Ca and P levels, PTH concentration and secretion of GH / IGH (Figure obtained from Gomez, 2006). 1.2.4.1- Parathyroid Hormone Parathyroid hormone (PTH) is the primary regulator of renal 1,25-dihydroxyvitamin D3 formation (Holick, 2006; Dusso et al., 2005; Bouillon et al., 1998; Issa et al., 1998). PTH regulates 1,25-dihydroxyvitamin D3 production directly through enhancing 1-ÃŽ ±-hydroxylase activity within kidney cells and increasing the genetic transcription rate of renal proximal tubular 1-ÃŽ ±-hydroxylase both of which result in an increase in the renal 1,25-dihydroxyvitamin D3 production rate. High levels of 1,25-dihydroxyvitamin D3 suppress the enzyme transcription activity and PTH concentration. Thus, renal 1,25-dihydroxyvitamin D3 has a negative feedback response on PTH secretion, providing an efficient regulatory control of renal 1,25-dihydroxyvitamin D3 homeostasis (Dusso, et al., 2005; Holick,2003; Sahota and Hosking, 1999; Reichel, et al., 1989; Iqbal, 1994). 1.2.4.2- Calcium Dietary calcium exhibits a direct regulatory influence on renal 1-ÃŽ ±-hydroxylase activity via fluctuating serum calcium concentration and indirectly via its effect on serum PTH concentration. Calcium exerts its effect through calcium-sensing receptor (CaR) activation within the parathyroid gland and renal proximal tubules cells in response to low calcium concentration. Thus, the low intracellular calcium levels lead to increased production of 1,25-dihydroxyvitamin D3 within renal cells (Ramasamy, 2006; Bland et al., 1999; Chattopadhyay et al., 1996). On the other hand, it has been shown that high calcium concentrations markedly impair renal 1,25-dihydroxyvitamin D3 formation in human nephrotic cell cultures and in parathyroidectomised animals (Bland et al., 1999; Chattopadhyay et al., 1996). An increase in extracellular calcium indirectly suppresses 1,25-dihydroxyvitamin D3 production at the proximal convoluted tubule by inhibiting PTH release (Deluca, 2004; Carpenter, 1990). Howev er, the detailed mechanism of calcium-sensing receptors (CaR) activation is not yet fully understood (Dusso, et al., 2005; Hewison, et al., 2000). 1.2.4.3- Phosphate Dietary phosphate intake and serum phosphate concentrations exhibit regulatory effects on 1,25-dihydroxyvitamin D3 production in proximal renal tubules. This effect has been demonstrated in several studies which showed that a decrease in dietary phosphate accelerated renal formation of 1,25-dihydroxyvitamin D3, but did not directly affect 1, 25-dihydroxyvitamin D3 catabolism. Conversely, elevated serum phosphate and increased phosphate intake led to decreased production of 1, 25-dihydroxyvitamin D3 (Carpenter, 1989; Reichel et al., 1989). Several studies have shown that inorganic phosphate levels have no significant direct effect on mitochondrial 1-ÃŽ ±-hydroxylase activity in cultured renal cells in the short term, suggesting that the action of inorganic phosphate is not mediated via changes in PTH and Calcium concentrations and is possibly inducted by other hormones such as growth hormone, insulin and insulin-like growth factor (Khanal et al., 2006; Dusso et al., 2005; Carpenter, 1 989). In recent studies, fibroblast growth factor 23 (FGF-23), frizzled-related protein 4 (FRP-4) and matrix extracellular phosphoglycoprotein (MEPE) have all been identified as potent and key regulatory factors of 1-ÃŽ ±-hydroxylase activity in renal cells. These factors act through a biphasic mechanism on renal phosphate homeostasis and modulate the circulating levels of 1, 25-dihydroxyvitamin D3 produced by proximal renal tubules (Dusso et al., 2005; Inoue et al., 2005; Mirams et al., 2004). 1.2.4.4- Calcitonin Calcitonin belongs to a family of calcium regulating hormones that is produced in the parafollicular cells of the thyroid gland, also known as C cells. It is a short and linear polypeptide with a molecular weight of only 3.7 kD. It is characterized by 32 amino acids and a disulfide bridge in the N terminal portion of the peptide. Calcitonin is secreted in response to increased free Ca2+ in blood and acts on osteoclasts, the bone resorbing cells, as a suppressor of bone dissolution. Although calcitonin decreases Ca+2 and inorganic phosphate in blood, it also has the ability to recruit phosphorus into other cells. In addition to these metabolic functions, it is also involved in the upregualtion of CYP27B hydroxylase through the protein kinase C pathway (Yoshida et al., 1999) via a phosphorylation cascade that activates cAMP and induces the expression of hydroxylase thereby activating the transformation of 25(OH) D3 to 1,25(OH)2 D3. In addition to the significant role as a calcium regulating hormone, calcitonin is also known to stimulate the production of vitamin D in tandem with PTH (Yoshida et al., 1999; Wongsurawat and Armbrecht, 1991). Previous studies revealed that 1-ÃŽ ±-hydroxylase mRNA expression, 1-ÃŽ ±-hydroxylase activity and the production of 25(OH)D and 1,25(OH)2D3 all increased in rat kidney cells following the administration of calcitonin (Yoshida et al., 1999; Galante et al., 1972; Rasmussent et al., 1972). However, in cases of diabetes, it is postulated that the kidney becomes immune to the effect of this hormone in diabetic rats which lead to increase vitamin D production (Wongsurawat and Ambrecht, 1991). 1.2.4.5- Growth hormone, Insulin and Insulin-like growth factor-1 Growth hormone (GH) has many regulatory actions in various metabolic processes in humans and mammals and its effect on mineral homeostasis in target organs such as bone and renal cells is well documented. While the regulatory effects of GH on dietary calcium and phosphate metabolism in different tissues have been established, its effect on vitamin D metabolism remains controversial. However, many studies have shown that GH increases the expression of 1-ÃŽ ±-hydroxylase and 1, 25-dihydroxyvitamin D3 in cultured cells and experimental animals (Gomez, 2006). Wu and colleagues reported that serum1, 25-dihydroxyvitamin D3 increases after GH administration in hypophysectomized rats fed with a phosphate depleted diet. Short-term studies in healthy humans have shown that GH raises 1-ÃŽ ±-hydroxylase enzyme activity and promotes 1, 25-dihydroxyvitamin D3 synthesis without changes in PTH, calcium and phosphate concentrations, suggesting that the increasing circulating levels of 1, 25-dihydroxy vitamin D3 following GH administration is not mediated by PTH action (Wu et al., 1997; Bianda et al., 1997; Wright et al., 1996). GH has also been shown to lead to increased production and serum concentration of 1, 25-dihydroxyvitamin D3 in pigs and in renal impaired prepubescent children. These are thought to be a result of the direct and indirect effects of GH on 1-ÃŽ ±-hydroxylase expression, and on calcium and inorganic phosphate homeostasis in renal tubules cells (Strife and Hug, 1996; Denis et al., 1995). However, the action of GH on vitamin D metabolism in vitro remains uncertain and may involve other regulatory factors such as PTH and Insulin-like growth factor-1 (IGF-1). It has been shown that GH does not raise 1, 25-dihydroxyvitamin D3 levels directly in cultured cells obtained from aged-rats; yet it stimulates calcium absorption and the expression of calcium binding proteins in vitro indicating that the effect of GH is mediated through the action of other factors such as IGF-1 (Fleet et al., 1991). Insulin is another key factor with a role in vitamin D homeostasis. Insulin significantly decreases renal hydroxylase activity and renal synthetic capacity of 1, 25-dihydroxyvitamin D3 in insulin deficient patients or those receiving insulin therapy (Armbrecht et al., 1996). However, a study of different routes of therapeutic insulin administration in human diabetic subjects concluded that insulin induces the hepatic hydroxylation of 25-hydroxyvitamin D3. This effect is related to the fact that insulin is a potent inducer of the vast majority of liver hydroxylases enzymes (Colette et al., 1989). This study also showed that there was no significant difference in circulating levels of 1,25-dihydroxyvitamin D3 between different methods of insulin administration. Serum 1,25-dihydroxyvitamin D3 is maintained at normal concentrations in those subjects on long term insulin therapy; however, continuous intraperitioneal infusion procedure (CPII) may augment hepatic 25-hydroxlase activity (Col ette et al., 1989). Similarly insulin has shown a significant effect on stimulating 1,25-dihydroxyvitamin D3 production through 1,25-dihydroxyvitamin D3 and PTH stimulation with no concomitant action on 24-hydroxylase expression in rat osteoblast cells when these cells were cultured with known concentrations of 1,25-dihydroxyvitamin D3 and PTH (Armbrecht et al., 1996). Insulin-like growth factor-1 (IGF-1) is a relatively small peptide that is primarily expressed in hepatic cells and to a lesser extent in some other cells and tissues. It has been identified as one of the potent regulatory components of mineral metabolism in humans and mammals. Recent studies on the metabolic effect of IGF-1 revealed that the administration of IGF-1 to aged laboratory animals, fed on a calcium- and phosphate- deficient diet, can restore 1-ÃŽ ±-hydroxylase activity and enhance the production of 1,25-dihydroxyvitamin D3. In contrast, there was no significant effect of IGF-1 on enzyme activity and 1,25-dihydroxyvitamin D3 levels in adolescent or elderly rats fed on a calcium and phosphate fortified diet concluding that the expression of IGF-1 is not age related but related to the dietary calcium and phosphorus status. (Gomez, 2006; Wong et al., 1997; Wu et al., 1997). In healthy human subjects, a significant effect of IGF-1 on renal 1,25-dihydroxyvitamin D3 synthesis wa s observed after short term infusion with IGF-1. There was no noticeable alteration of the levels of circulating calcium, phosphate and PTH highlighting the role of IGF-1 in stimulating renal expression of 1-ÃŽ ±-hydroxylase and 1,25-dihydroxyvitamin D3 formation in conjunction with GH, independently from PTH (Bianda et al., 1997). In vitro studies have shown that IGF-1 influences the expression of 1-ÃŽ ±-hydroxylase and 1,25-dihydroxyvitamin D3 synthesis in cells cultured from non renal human tissues. Halhali and colleagues demonstrated that IGF-1 noticeably elevates both the enzyme activity and 1,25-dihydroxyvitamin D3 levels when added into cultured syncytiotrophoblast cells obtained from human placental sources. This study demonstrated that IGF-1 strongly enhances the ability of non renal cells to produce 1,25-dihydroxyvitamin D3 without involvement of GH and PTH (Halhali et al., 1997). 1.2.4.6- 1, 25-dihyroxy vitamin D3 The circulating levels of 1,25-dihydroxyvitamin D3 modulate its production by renal cells through an indirect negative feedback mechanism. This mechanism appears to reduce the likelihood of vitamin D toxicity by inhibiting 1,25-dihydroxyvitamin D3 synthesis by an indirect mechanism that controls the 1-ÃŽ ±-hydroxylase gene expression at the molecular level rather than inhibiting 1,25-dihydroxyvitamin D3 synthesis directly. However, the exact mechanism is not yet fully understood (Dusso et al., 2005; Deluca et al., 1990). A recent study examined the effect of 1,25-dihydroxyvitamin D3 on 1-ÃŽ ±-hydroxylase production by cultured human keratinocytes. Keratinocytes were cultured with labeled 25-hydroxyvitamin D3 and different concentrations of 1-ÃŽ ±-hydroxylase mRNA and 24-hydroxylase- suppressed proteins. The 1,25-dihydroxyvitamin D3 did not suppress either the 1-ÃŽ ±-hydroxylase activity or the rate of gene transcription. The study implied that metabolic regulation of 1,25-dihydroxyvi tamin D3 is related to the molecules biodegradation in response to augmented 24-hydroxylase activity rather than 1,25-dihydroxyvitamin D3 formation by 1-ÃŽ ±-hydroxylase (Xie et al., 2002). In addition, Wu and colleagues demonstrated a possible alternative mechanism of 1,25-dihydroxyvitamin D3 synthesis linked to the fact that both 24-hydroxylase and 1-ÃŽ ±-hydroxylase enzymes share equivalent metabolic capability and they proposed the possibility of protein- protein interaction between intracellular vitamin D binding protein and 1-ÃŽ ±-hydroxylase (Wu et al., 2002). 1.2.5- Vitamin D Transport, receptors and mechanism of action Vitamin D receptor (VDR), also known as calcitriol receptor, is a member of the steroid family and belongs to the nuclear receptor superfamily (NHR). Human VDR until recently was thought to comprises four functional units with a total of 427 amino acids residues with an estimated molecular weight of about 48 kDa. These units are the DNA binding domain (DBD) or C domain, the D domain and the ligand binding domain (LBD) or E domain. More recently, a carboxy-group with undefined function, known as the F region has been identified (Christakos et al., 2003; Aranda and Pascual, 2001; Rastinejad et al., 2000). These units as, shown in figure 4, are also known as A/B domain. The A/B region of VDR contains a low number of amino acids that participates in essential ligand-independent receptor stimulation (Aranda and Pascual, 2001; Issa et al., 1998). It is not yet clear if the deletion of A/B domain from VDR will compromise ligand binding, DNA binding or its transactivation features (Issa et a l., 1998). In contrast, the structure of the DNA binding domain or C region among NHRs comprises 40% unique amino acids sequences and a domain of more than 67 resemble amino acids residues (Rastinejad et al., 2000). Moreover, the core structure of DBD comprises between 22 and 114 amino acid residues, nine of them are cysteines. Eight of cysteine residues orchestrate with zinc atoms in tetrahedral fashion to form a dual â€Å"zinc-like finger† DNA binding configurations containing approximately 70 amino acids with a carboxy-terminal extension (CTE). This encloses T and A boxes in a dual helix molecule in which one helix is essential for definitive interaction with the main domain on DNA while the second helix takes a part in receptors structural properties (i.e. receptor dimerization) (Aranda and Pascual, 2001; Issa et al., 1998). However, the integration of the structural amino acids of the DBD ÃŽ ±-helix one, at the site of the first zinc atom, determines the selectivity and specificity of recognition of DBD and forms an area known as the â€Å"P Box†. Similarly; the integration of amino acids at the position of the second zinc atom modulates the formation of a configuration termed the â€Å"D Box† which forms a dimerization interface zone (Aranda and Pascual, 2001; Rastinejad et al., 2000; Issa et al., 1998). Furthermore the vast majority of DBD amino acid units are basic amino acids which enhance the non-covalent binding of the DNA helix at the negatively charged phosphate group (Issa et al., 1998). The ligand binding domain (LBD) or E domain has a spherical configuration with many functional regions composed of 12 cohered helix anchors defined as H1 to H12. LBD itself comprises a net of 427 amino acids which contribute to homodimerization and heterodimerization and the interaction of hormones and costimulaotors by a crucial transactivational mechanism (Aranda and Pascual, 2001; Weatherman et al., 2000; Issa et al., 1998). Crystallograp hic studies show that LBD have two cohered and integrated domains, the Ti or â€Å"signature motif† and the carboxy or C terminal AF-2 providing the self-ligand transcriptional properties; hence a higher degree of attraction of 1,25 dihydroxyvitamin D3 binding is observed at 382 to 402 of LBD amino acid sequence and any genetic aberration at this particular amino acids sequence will diminish the interaction capability of LBD (Aranda and Pascual, 2001; Issa et al., 1998). Figure 4: The primary structure of the vitamin D receptor (VDR) and the binding of retinoid X receptor (RXR)-VDR heterodimers to vitamin D response elements (VDREs) in the form of DR3 and ER6 motifs. (Figure from Lin and White, 2003) 1,25-dihydroxyvitamin D3, has been identified as steroid hormone with a mechanism of action similar to other steroid hormones, causing new protein expression in various target organs. Based on the nuclear receptors structural studies, calcitriol is known to exert its biological action through binding with VDR in the cell nucleus to mediate a cascade of transcriptional and translational processes resulting in either the regulation or inhibition of new protein expression in target tissues or the binding to plasma membrane receptors without stimulating new protein synthesis (Nezbedova and Brtko, 2004; Reichel and Norman, 1989). Two different receptors for 1,25-dihydroxyvitamin D3 have been recognized in different target cells; identified as genomic VDRnuc and typical VDRmem .These receptors provide the best dynamical conformational forms for calcitriol interaction and to evoke its genomic and non-genomic effects (Norman et al., 2002). The binding of 1,25-dihydroxyvitamin D3 to VDRnuc e nhances the interaction with an undistinguished protein known as the nuclear accessory factor (NAF) and to the caroxy-terminal of VDR. This interaction leads to a structural conversion pattern of the C-terminal of VDR allowing the AF-2 domain to attach with other transcriptional elements such as SCR-1, calcium binding protein (CBP) and P300. This promotes the binding of the heterodimer molecule with DNA at the vitamin D response sites (VDRE) and directs its transcriptional gene activity (Jones et al., 1998; Iqbal, 1994). In addition, these coactivators play a role in DNA configurational changes through histone acetyl transferase activation pathway of the core components of histones. This results in mechanical instability of the DNA structure and enhances the net binding capacity of the coactivators with their corresponding receptors at nucleosomal histone level and leads to the upregulation of these transcriptional coactivators which in trun, accelerate the net gene transcriptional rate to promote the synthesis of the analogous protein (Lipkin and Lamprech, 2006; Jones et al., 1998). Conversely, the non-genomic or classical effect of 1,25-dihydroxyvitamin D3 is modulated through its binding with the surface cellular membrane receptor known as mVDR which initiates an immediate response in various target tissues with no genomic transcriptional activity. Many studies demonstrate the rapid effect of calcitriol in rapidly increasing both the level of circulating calcium and its absorption rate in animal intestines, evoking phosphoinoisitide bioactivation, cyclic guanosine monophosphate (cGMP) elevation, activation of protein kinase C and triggering the mitogen activated protein kinase pathways and involving the chloride gates action potential in different organs (Dusso et al., 2005; Nezbedova and Brtko, 2004; Boyan and Schwartz, 2004; Norman et al., 2002). The entire mechanism, as shown in figure 5, for the rapid effect of calcitriol remains doubtful, however; the proposed mechanism is mediated through the interaction with mVDR leading to a series of intracellular sig naling events. Signaling is orchestrated by the activation of various metabolic pathways involving different transportation mechanisms of certain mineral components of target organs. (Pedrozo et al., 1999; Norman et al., 1999; Revelli et al., 1998). However, other studies reveal that the genomic effect of 1,25-dihydroxyvitamin D3 is independent of its non-genomic mechanism (Dusso et al., 2005). Figure 5: Cellular mechanism of action of 1,25(OH)2D3 (Figure from Horst et al., 1997) 1.3- Biological actions of Vitamin D on target tissues and Systems The active form of vitamin D, 1,25-dihydroxyvitamin D3 is well recognized as a member of steroid hormones that mediates several metabolic and non-metabolic processes in various organs in human and animals as shown in figure 6. 1.3.1- Intestine Mineral absorption in the intestines is increased in the presence of the hormone 1,25(OH) vitamin D. However without this, only 10 to 15% of dietary calcium and 60% of phosphorus is absorbed from the diet (De Luca, 2004). Ca2+ and HPO42- are also absorbed when intestinal cells interact with the vitamin D- VDR- RXR complex. The latter enhances the expression of the epithelial calcium channel and calcium-binding protein which recruits calcium and phosphorus (Holick, 2007). Knock out mice experiments studying the effect of VDR gene deletions also show that the size of the small intestines is related to the levels of calcitriol and dietary calcium availability. Vitamin D deficient mice fed with diets low in calcium exhibited the largest small intestine to large intestine ratio (Cantorna et al., 2004). VDR knock-out mice experiments also aid in the discovery of calcium channels, the route for Ca absorption, in the intestine (Peng et al., 1999). Calbindin is a potent calcium transporter in mammals which characterized by a high affinity for calcium ions. Therefore, the binding of vitamin D to VDR and RXR signals an increased production of calbindin which facilitates systemic Ca2+ ions transportation and prevent the occurrence of calcium toxicity in the intestines. Figure 6: Schematic diagram of the effects of Vitamin D on different tissues and organs (Figure from Holick, 2007). 1.3.2- Bone Takeda et al. (1999) studied the role of vitamin D and VDR in bone cells using knock out mice experiments. Their results showed that bone cells formation triggering mechanisms such as cell to cell interaction between osteoblast and osteoclast progenitors and stromal cells induced by 1,25(OH)2 vitamin D3 and provoke the formation of osteoclasts. In their capacity as bone resorbing cells, osteoclasts can be triggered by low serum calcium levels, to break down bone and free calcium back in to the blood thus redistributing calcium throughout the body. However, this does not occur without the expression of VDR and without vitamin D complexing with its receptor. This study emphasizes the important role of recognition sites on the VDR and the structural implications that the receptor-ligand binding has on VDREs and transcription initiation. Although the effects of PTH

What are Ontology and Epistemology? Essay -- Philosophy, Truth

What are ontology and epistemology and why are they important in social science research Introduction The study of any particular science involves embracing particular and specific ontology, epistemology and methodologies that are different from each other. Ontology is the concept that defines and explains the essential types of truth (Blaikie 2009). Every field of science constitutes its own ontology and in most cases two types of ontology exists: formal ontology and domain ontology (Blaikie 2009). Formal ontology type of research always postulates something general related to reality while on the other hand domain ontology postulate something specific with regard to different types of truths (Blaikie 2009). On its part epistemology constitute a science concept that defines how human and the general population of the world know and reason the particular truth. The two concepts are differentiated by particular assumptions that are associated with each of them. For instance assumptions associated with ontology include: shallow realist, conceptual realist, cautious realist, depth real ist and idealist (Blaikie 2009). On the other hand assumptions related to epistemology include: empiricism, rationalism, falsificationism, neo-realism and constructionism (Blaikie 2009). Therefore the purpose of this essay will be to define objectivism and inteprativism as related to ontology, define positivism and interpretavism as related to epistemology, explain how ontology and epistemology are linked and how they influence each other, before lastly looking at how important ontology and epistemology are. Objectivism and interprativism in ontology Blaike (2000) asserted that ontology to involve, â€Å"claims and assumptions that are made about natur... ...oherent research practice functions to collect and communicate information about the world, a scenario enabled by key concepts of ontology and epistemology. Conclusion Social reality in general is viewed as a complex of causal relations between events that are depicted as patchwork of relationships between variables. Generally, causes of human behavior are regarded as being external to the individual and knowledge is seen to be derived from sensory experience by means of experimental or comparative analysis and concepts and generalizations are summaries of particular observations. In reality, claims have been made about what is observed with the senses is what is real and that scientific laws are similar with empirical regularities. In summary, key concepts of ontology and epistemology have played important role in shaping and guiding social research processes.

P Evaluation

Carry out a risk assessment In a health and social care setting using the Information you have planned with your class put together a risk assessment on the findings of the residential home. MM- Assess the hazards identified in the health or social care setting Del- Make recommendations in relation to identify hazards to minimize the risks to the service user group Type of Hazard Risk caused Probability of hazard Severity of hazard Risk Factor How can the risk be reduced/prevented?Water or any liquids of the floor. Service users and staff slipping and tripping on the water, resulting In Injury. 4 24 HIGH When there Is water or any liquids on the floor, stay by the spillage till another member of staff bring the warning wet floor sign. Once the sign has been put over the spillage, clean up the spillage to reduce the risk of someone slipping/tripping over. Fire Service users and staff suffering from getting Injured from burns, or Inhaling high dosages of smoke from the fire. 7 14 MEDIU M Ensure that all fire alarms are working correctly, so they are able to detect a fire quickly. Also ensure that all members of staff and service users known the fire safety procedures so they know the easiest and safest route out of the building to prevent themselves from getting injured. Also ensure that lifts are closed off and out of use, to prevent service users and staff from using them, and causing further Injury.Incorrect use of medication Service users taking either too much medication or not enough medication or not the erect medication that will result in further injury. 3 Ensure that all medication within the residential home is clearly labeled with the name of the medication, and what the medication is used for to cure. Also ensure that all members of staff within the residential home Is fully trained of what medicines should be used and what they should be used for. Electricity appliances glass to smash, as well as electrical appliances blowing up and setting on fire. 4 8 LOW Ensure that all electrical appliances are tested regularly, to ensure that none of the electrical appliances are broken or faulty which may result in a fire. Food Food can become contaminated which can result in germs being spread and resulting in staff members and service users becoming ill. 2 Ensure that all members of staff wear clean suitable clothing such as gloves, hair tied up and blue plasters on when they have cut themselves as well as washing their hands regularly to prevent germs from being spread and food contamination from occurring.

Boa Constrictor Facts

Boa Constrictor Facts Boa constrictors are reptiles and reside mainly in Central and South America. Their scientific name, Boa constrictor, is derived from the Greek words meaning type of snake (boa) and to grasp (constrictor). They are known for their gigantic size and for killing their prey by squeezing them to death with their muscular bodies. Fast Facts: Boa Constrictor Scientific Name: Boa constrictorCommon Names: Red tailed boa, boasOrder: SquamataBasic Animal Group: ReptilesDistinguishing Characteristics: Large, heavy-bodied, beige blotches on brown bodySize: 8-13 feet in lengthWeight: 20-100 poundsLife Span: 20-40 yearsDiet: CarnivoreHabitat: Tropical forests, grasslandsConservation Status: Least concernFun Fact: Boas are excellent swimmers, but they avoid water as much as possible Description Boa constrictors are non-venomous snakes best known for their large size and for squeezing their prey to death. They can climb surfaces well, swim, and travel up to speeds of one mile per hour. These reptiles have a life span of roughly 30 years, but the oldest ones have lived to 40 years. They can grow up to 13 feet in length and weigh from 20 to 100 pounds. The colors of their skin, such as pinkish-tan with patterns of brown and red, help to camouflage them well in their environment. Habitat and Distribution Boa constrictors live in Central and South America in habitats such as tropical forests, savannas, and semi-deserts.  Boas hide in the burrows of rodents at ground level during the day to rest. They are also semi-arboreal and spend time in the trees to bask in the sun. Diet and Behavior The tail of a rat hangs from the mouth of a boa constrictor as it ingests the body of the rat.   Joe McDonald/Corbis Documentary / Getty Images Boas are carnivores, and their diet consists mainly of mice, small birds, lizards, and frogs when they are young. As they mature, they eat larger mammals, such as rodents, birds, marmosets, monkeys, opossums, bats, and even wild pigs.   At night, boas hunt using sensing pits on their face that allow them to detect their preys body heat. Because they move slowly, boas rely on ambushing their prey; for instance, they may attack bats as they sleep in trees or as they fly by. They kill by using their powerful muscles to squeeze their victims body. Scientists thought this squeezing suffocates their prey, but recent findings show that the powerful pressure from the snakes actually constricts blood flow in the animal. The pressure is so powerful that the prey’s heart is not able to overcome it and it dies within seconds. Once the animal is dead, these snakes swallow their prey whole. They have special tubes in the bottom of their mouth that allow them to breath as they eat their meal. Boa constrictors digest their food with their powerful stomach acids. After a large meal, they will not need to eat for several weeks. Since they are nocturnal and solitary creatures, boas hide in rodent burrows during the day to rest, but may spend several hours in trees basking in the sun. During colder weather, they can become almost completely inactive. Reproduction and Offspring Boa constrictors reach mating age at around 3-4 years. The breeding period for them is during the rainy season. Males slither across the female’s body to stimulate the cloaca with his vestigial legs. Females produce anywhere from 20 to 60 young. These reptiles are ovoviviparous, which means that they give birth to young that are fully formed. The female eats very little during the gestation period, which lasts roughly 100 days. When the eggs are ready to be born, they push out the cloaca and must break open the protective membrane they are still encapsulated in. At birth, the young are about 20 inches and can grow to 3 feet during the first several months of life. They can survive on their own and demonstrate natural instincts for hunting and hiding from predators. Conservation Status Boa constrictors are designated as least concern under CITES Appendix II, but they have not been assessed by the International Union for Conservation of Nature (IUCN). The biggest threat to boas comes from humans who harvest them for their skin as part of the leather trade. In tropical parts of the Americas, people may bring boas into their homes to manage rodent infestations. Species There are over 40 species of boas. A few examples of species are the rubber boa (Charina bottae), the rosy boa (Charina trivirgata), and the red-tailed boa (Boa constrictor constrictor). Rubber boas live in western North America. As their name suggests, these boas have rubbery skin, and they burrow into the ground. The rosy boa’s habitat ranges from California and Arizona to Mexico. The red-tailed boa is the species of boa constrictor that is most commonly used as a pet. Boa Constrictors and Humans Workers displaying yellow boa constrictor at a festival in Bowie, Maryland.   Tom Carter/Photolibrary/Getty Images Plus In the U.S., boa constrictors are often imported as pets and sometimes bred to produce more colorful snakes. While this pet trade may not pose a threat to boas, an unfortunate risk is that some owners simply release their pets into the environment because they do not realize how quickly these animals grow. This is particularly dangerous because boas can adapt well to new environments so long as the temperatures are conducive to them thriving. As a result, they can become an invasive species and pose serious threats to the new environment, which could lead to the disappearance of other indigenous species. Sources â€Å"Boa Constrictor.† Boa Constrictor, www.woburnsafari.co.uk/discover/meet-the-animals/reptiles/boa-constrictor/.â€Å"Boa Constrictor.† Kids National Geographic, 1 Mar. 2014, kids.nationalgeographic.com/animals/boa-constrictor/.  Ã¢â‚¬Å"Boa Constrictor.† Smithsonians National Zoo, 28 Nov. 2018, nationalzoo.si.edu/animals/boa-constrictor.  Boa Constrictor Facts and Information. SeaWorld Parks, seaworld.org/animals/facts/reptiles/boa-constrictor/.  Britannica, The Editors of Encyclopaedia. â€Å"Boa.† Encyclopà ¦dia Britannica, Encyclopà ¦dia Britannica, Inc., 14 May 2019, www.britannica.com/animal/boa-snake-family.

Free Essays on The Big Lebowski

All of the relationships among the elements in the film the Big Lebowski may seem to be enigmatic with each other, but this style of film creates an integrated system of disunity. The Coen brothers demonstrate this style through various motifs through out the film, from the main character's name to what he drinks. The film is a perfect example of a film which has the theme of disunity. In the film the main character Jeffery Lebowski, refers to himself as "the Dude". This element of the story becomes a motif. The Dude is referred to, and refers to himself as the Dude because it represents his personality, which is an easygoing "cool" character. The common Western society slang which is associated with the word dude, is male prostitute. In the scene where the Dude returns home after being arrested in Malibu, he find himself engaging in sexual intercourse at the request of Mod Lebowski. After they finish, Mod explains to the Dude that she was using him to concede a child. Obviously he was not given money in exchange for sexual favours but, the Dude, (much similar to real prostitutes) was used for sex. The Dude is continuously used by his friends and business associates through out the whole film. Although presented as a laidback cool character, the Dude's title is representative of how he is seen by everyone around him. In the film, Bowling is seen as a man's activity, a place where go to compete and get away from the world. In the bowling alley there is never a female present in the shot within any scene. This motif is reinforced during the scene entitled Gutter Balls. In the Dude's trip-out it starts off as a bowling spoof pornographic film, which can also be considered a male thing. It has shots of floating bowling pins and balls rearranged in numerous sexual positions, where the pins represent the male genitalia. Further on in the dream, Mod, who is a strong independent character, is represented by Viking costume she is wearing. Cont... Free Essays on The Big Lebowski Free Essays on The Big Lebowski All of the relationships among the elements in the film the Big Lebowski may seem to be enigmatic with each other, but this style of film creates an integrated system of disunity. The Coen brothers demonstrate this style through various motifs through out the film, from the main character's name to what he drinks. The film is a perfect example of a film which has the theme of disunity. In the film the main character Jeffery Lebowski, refers to himself as "the Dude". This element of the story becomes a motif. The Dude is referred to, and refers to himself as the Dude because it represents his personality, which is an easygoing "cool" character. The common Western society slang which is associated with the word dude, is male prostitute. In the scene where the Dude returns home after being arrested in Malibu, he find himself engaging in sexual intercourse at the request of Mod Lebowski. After they finish, Mod explains to the Dude that she was using him to concede a child. Obviously he was not given money in exchange for sexual favours but, the Dude, (much similar to real prostitutes) was used for sex. The Dude is continuously used by his friends and business associates through out the whole film. Although presented as a laidback cool character, the Dude's title is representative of how he is seen by everyone around him. In the film, Bowling is seen as a man's activity, a place where go to compete and get away from the world. In the bowling alley there is never a female present in the shot within any scene. This motif is reinforced during the scene entitled Gutter Balls. In the Dude's trip-out it starts off as a bowling spoof pornographic film, which can also be considered a male thing. It has shots of floating bowling pins and balls rearranged in numerous sexual positions, where the pins represent the male genitalia. Further on in the dream, Mod, who is a strong independent character, is represented by Viking costume she is wearing. Cont...

Port Security Assignment Example | Topics and Well Written Essays - 1000 words

Port Security - Assignment Example Since great numbers of trucks move in and out of ports it is easier for the terrorist to carry harmful things to the port vicinity. Some ports also have fishing and recreational boats that terrorists could use as an aid in performing their terrorist activities. Terrorist can use the shipping system to import weapons of mass destruction and other hazardous materials. Even smuggling of personnel can be a thing of major threat. If terrorist attack the sea port with nuclear bomb a large area can be destroyed. Seaports attack can cause local and international destruction as it is globally connected. As there is lot of embarkation and disembarkation happening in the sea ports it is difficult to detect mal practices. Radical elements can import biological and chemical weapons to destroy the country which is a matter of great concern. The coast guards are the major unit active in the port area to maintain the security system. The security atmosphere at seaports remains uncertain because of port infrastructure remaining uncompleted and also due to lack of proper co ordination in conveying of information about threats. â€Å"There is a wide range of vulnerabilities at seaports, including critical infrastructure such as bridges and refineries, shipping containers with unknown contents, and the enormous volume of foreign and domestic shipping traffic† (Decker,2002). Ports operate in a complex mode transport system, and weak linkages between components may result higher vulnerability Large scale military deployment would require to transport equipment needed by military heavily by sea .If the ports are attacked there could be a severe civilian causality and they could lose time and also cargo. Since infrastructure is inefficient the full potentiality of deployment cannot be utilized. There is lack of central authority to monitor the activities of the personnel installed along the ports. Moreover during the course of deployment there can be non government

Gender is not something one is, it is something one dose it is a Essay

Gender is not something one is, it is something one dose it is a sequence of acts, a doing rather then a being - Essay Example Butler (1986) states that the common thinking about how a female becomes a woman is governed by patriarchy and phallogocentric language â€Å"which precedes and determines the subject itself† (Butler, 1986, p. 36). In other words, Butler (1986) believes that the term â€Å"woman† is defined passively, not by the women themselves, but by the patriarchal culture. That said, de Beauvoir (1973) believes that oppression is not inevitable, but, rather, they persist because of cultural reasons. Butler (1990) further states that the concept of a universal patriarchy has come under fire, because patriarchy exists in â€Å"concrete cultural contexts† (Butler, 1990, p. 3). Butler (1990) also states that there is the possibility that women might have a bond through their oppression alone. Connell (1992) further states that gender, in and of itself, is a construction of power and hegemony, which means that the male identity is also influenced by culture and these outside forc es. Connell (1992) believes that masculine identities may be hegemonic or marginalized – some masculine identities are the former, others are the latter. Similarly, there is a difference between masculinity and femininity, and this, too, is contrasted with the terms â€Å"male† and â€Å"female.† Bartky (2003) states the one achieves femininity, whereas one is born female. The same with masculinity – men might achieve masculinity, and be born male, or, alternatively, as with many homosexual men, one may be born male but not achieve masculinity. As with the philosophies of de Beauvoir and Butler, Bartky (2003) states that the concept of masculinity and femininity is dictated by the power structure, which states what the contours are of masculinity and femininity (Bartky, 2003). This article will examine how patriarchy and society has defined both men and women throughout the modern era. Discussion Standards of Beauty As de Beauvoir (1973) states, the femin ine identity, and what it means to be a woman is defined by patriarchy and the male. In no area of a woman’s life is this more apparent than the standards of beauty, which are male-dominated. Women feel that they must conform to these male-dictated beauty standards, or they are somehow less than. The feminine ideal for beauty, therefore, is not only ever-changing, but is dictated by the power structure and patriarchy. Lorber (1993) states that the feminine ideal, at least during the early 1990s, which is when Lorber’s article was written, was slim-slim-hipped, small breasted and virtually emaciated. Women starved themselves for this ideal, and this ideal sold many magazines which promised women a way to become thinner, in order to fit this ideal. While this was the ideal in the early 1990s, and, more or less, continues to be today’s ideal, this was not always so – the feminine body ideal has changed over the years, according to society and culture. Calabr ese et al. (2011) state that the feminine ideal is epitomized by Playboy models, which is similar to the ideal stated by Lorber (1993), in that the women is to be slim-hipped and slender, overall. However, in this ideal, the woman must also have large breasts. Barbie dolls exemplify this ideal, and girls and women increasingly pressured to fit this ideal, to the extent that they require plastic surgery to do so (Calabrese et al.., 2011). Frederick et al. (2007) state that these feminine ideals, as pushed upon society by